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Arizona State University MCB PhD student

The cell uses membrane bound organelles (mitochondria, endoplasmic reticulum) to separate opposing reactions and provide ideal conditions for efficiency and regulation - a process called cellular compartmentalization. My thesis work in the Kruer Lab is focused on understanding the cellular mechanisms behind Coenzyme A (CoA) compartmentalization. CoA is a cofactor best known for its role in cellular metabolism including the TCA cycle and lipid metabolism. I am especially interested in how changes to compartmentalized CoA levels regulate metabolism and stress responses, and by what mechanisms this takes place. Long-term we hope our research on intracellular CoA handling will lead to new treatment options for CoA associated diseases, especially the childhood neurodegenerative diseases PKAN, CoPAN and MECREN

Sandra Hinz, MS: TeamMember
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