DEEP BRAIN STIMULATION

Deep brain stimulation (DBS) is an advanced neurosurgical therapy that uses implanted electrodes to deliver targeted electrical stimulation to specific regions of the brain in order to modulate abnormal neural activity. Originally developed for movement disorders such as Parkinson’s disease and dystonia, DBS has emerged as a powerful platform for both therapeutic intervention and neuroscience discovery by providing direct access to the functional dynamics of human brain circuits.

 

At the Kruer Lab, we leverage DBS alongside computational analysis of local field potential recordings to investigate the neural mechanisms underlying pediatric movement disorders. By integrating electrophysiology, neurogenetics, and molecular biology, our research aims to identify disease-specific biomarkers, uncover the biological pathways driving abnormal motor function, and advance the development of more precise and personalized therapeutic strategies.