The Molecular Basis of Neurodevelopment & Neurodegeneration

The Kruer laboratory’s goal is to unravel the molecular and cellular mechanisms that lead to developmental and degenerative movement disorders of childhood in order to better diagnose and treat these disabling conditions. Pediatric movement disorders can affect a child’s ability to speak, walk, and use their hands purposefully. Existing treatments for pediatric movement disorders are often inadequate, and the genetic basis of the disease is often unknown. Our work is inherently translational but focused on fundamental mechanisms that alter metabolism, early neuronal development, and cellular responses to cytotoxic stressors.